Batch 001 - Live Allocation

Next Release: Aug 2026

Vivre Labs

Institutional Longevity

Catalogue
Single-vial Blends · one injection
Clinical Details

- Peptides -

- Single-vial Blends -

- Goals -

- Clinical Reference -

- Guides -

- Integrity -

◇ Compound Reference

METABOLIC COENZYMEInvestigationalMost Prescribed

NAD+

High-Dose IV · 500mg

Status

Investigational

Route

SubQ / IV

Half-life

IV infusion: cellular uptake and conversion to NAD+ pools is rapid

Class

Coenzyme precursor

MechanismMitochondrial NAD/NADH Restoration

Cohort241 active prescriptions

Educational reference only - not a prescription or dosing recommendation. Some compounds are investigational or used off-label; suitability, dose, and monitoring are determined by your supervising physician. See Informed Consent & Disclaimer.

V-Series Member

$70 USD/vial

À-la-carte: $80 USD/vial · Save 13%

Vials per allocation

Member total (1×)$70

À-la-carte total$80

Flat per-vial pricing. Quantity is allocated and dispensed within your physician-supervised protocol - not a direct sale.

What this is

Nicotinamide adenine dinucleotide infusion. Restores cellular energy metabolism and supports sirtuin-mediated DNA repair pathways.

High-Dose IV · 500mg per vial · dispensed after a physician review.

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Janoshik Verified

HPLC + MS purity, every batch

Independent third-party lab

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COA Per Batch

Lot-level certificates published

Labeled vs actual mg disclosed

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Protocol Reviewed

Used in V-Series clinical stacks

Phase 1 supervision onboarding

Used inV-Series

V-02

Focus - Memory & Mental Clarity

NAD+ · Metabolic Coenzyme

◆ Certificate of Analysis · NAD+

JANOSHIK ANALYTICALHPLC + MS · Independent third-party

Lot-specific COAs for NAD+ are published with each batch release. Sample certificates available on request via partnerships@vivrelabs.com.

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Clinical Overview

NAD+

Nicotinamide Adenine Dinucleotide is the universal coenzyme for cellular energy metabolism, present in every cell. NAD+ levels decline significantly with age.

Direct intravenous administration restores cellular NAD+ pools faster than oral precursor supplementation.

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NAD+ Restoration

Restores cellular NAD/NADH ratio.

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Sirtuin & Repair

Activates sirtuins and supports PARP-mediated DNA repair.

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Mitochondrial Energy

Enables mitochondrial electron transport.

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Mechanism

How It Works

Restores cellular NAD/NADH ratio. Activates sirtuins (SIRT1-7), supports DNA repair via PARP enzymes, and enables mitochondrial electron transport.

Distinct from NAD precursors (NMN, NR) in providing direct cofactor restoration.

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Patient Bloodwork Guide

Bloodwork for Longevity & Mitochondrial Protocols

Cellular / mitochondrial - SS-31, MOTS-c, Epithalon, NAD+, V-04

These protocols target cellular energy, mitochondrial function, and markers of biological aging. Monitoring here is less about week-to-week safety and more about confirming the protocol is moving the deeper markers it is meant to.

Incremental approach. V-04 is introduced in phases (structural support first, then signaling, then a short telomere overlay) at conservative doses. Re-testing at the 6-month mark is how progress is judged.

Biological-age markers

Horvath methylation clockAn epigenetic estimate of biological age - the headline longevity marker, retested over months.

Telomere lengthTracks cellular aging at the chromosome level.

Mitochondrial & oxidative

Lactate (fasting & post-exercise)Healthy mitochondria clear lactate quickly. A high or slow-clearing level suggests cells are leaning on less-efficient anaerobic energy; a downward trend over time points to improving mitochondrial efficiency.

Lipid-peroxidation markers (MDA, 4-HNE)Signals of oxidative damage to cell membranes. Relevant to SS-31, which works by protecting the mitochondrial membrane lipid (cardiolipin) - a fall in these markers is a sign that structural protection is taking hold.

Fasting insulin & HOMA-IRA measure of how efficiently muscle takes up glucose. Relevant to MOTS-c, which supports muscle glucose uptake via the AMPK pathway - improvement shows as lower fasting insulin and a lower HOMA-IR score.

8-OHdGA marker of oxidative stress / DNA damage.

CoQ10A cofactor your mitochondria use to move electrons and produce energy.

Functional capacity

VO₂max / Zone-2 thresholdThe functional read-out of mitochondrial fitness - measured during graded exercise testing. As mitochondria adapt, the point where your body shifts from burning fat to burning carbohydrate moves, reflecting better aerobic capacity. A physical metric, not a blood test.

Routine safety

Fasting glucose & CMPStandard metabolic and organ-function checks.

When the tests happen

BaselineHorvath clock, telomere length, 8-OHdG, CoQ10, lactate/pyruvate, CMP.

Through the protocolSymptom and energy tracking; routine glucose/CMP.

Month 6Repeat Horvath clock + key markers to judge progress.

Educational only - not medical advice or a dosing instruction. Your physician orders the tests, sets your dose, interprets results, and decides if a protocol is right for you. See the Informed Consent & Disclaimer for full terms.

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Technical Profile

Measurable Properties

Class	NAD+ (nicotinamide adenine dinucleotide) - coenzyme
Mechanism	Central redox/again-related coenzyme; substrate for sirtuins, PARPs - biochemistry well-established
Pharmacokinetics	IV bioavailability route-dependent; cellular uptake debated
Evidence base	Biochemistry strong; clinical anti-aging outcome evidence limited
Form	IV / injectable under clinical protocol
Regulatory status	Not an approved anti-aging therapy; physician-supervised administration only

Certificate of Analysis (per batch)

Analytical method: UHPLC-MS. Batch COA available on request - link to be populated per shipment.

COA link - pending per batch

Biochemistry well-established but clinical outcome evidence limited - distinction stated honestly. Educational only.

Clinical Literature

Peer-Reviewed References

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

Martens CR, Denman BA, Mazzo MR, et al. · 2018 · Nature Communications 2018;9:1286

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Findings

Randomized, double-blind, placebo-controlled crossover trial in 30 healthy middle-aged and older adults. Chronic NR supplementation was well tolerated and effectively elevated NAD+ metabolites in peripheral blood. Reductions in systolic blood pressure and aortic stiffness were observed, suggesting potential cardiovascular benefit. Findings have not been uniformly replicated in subsequent NR trials with broader populations; mechanism is established, clinical-outcome translation is still developing.

View on publisher ↗

Nicotinamide riboside augments the aged human skeletal muscle NAD+ metabolome

Elhassan YS, Kluckova K, Fletcher RS, et al. · 2019 · Cell Reports 2019;28:1717–1728

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Findings

Controlled human study in older adults using the NAD+ precursor nicotinamide riboside (NR). Demonstrated increased muscle NAD+ metabolite concentrations and shifts in skeletal-muscle gene expression linked to mitochondrial pathways. Effects on functional outcomes were modest. The NAD+ biochemistry is well-established; direct clinical anti-aging outcome evidence remains limited and active research continues.

View on publisher ↗

Boosting NAD level suppresses inflammatory activation of PBMCs in heart failure

Zhou B, Wang DD, Qiu Y, et al. · 2020 · Journal of Clinical Investigation 2020;130:6054–6063

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Findings

Clinical study in patients with heart failure assessing NAD+ restoration via NR supplementation. NAD+ augmentation was associated with reduced pro-inflammatory cytokine activation in peripheral blood mononuclear cells and improved markers of mitochondrial function. Evidence supports the broader rationale that NAD+ availability modulates inflammatory signalling in disease states; not yet translated to mortality-or-event endpoints in randomised outcomes trials.

View on publisher ↗

NAD+ biochemistry is well-characterised; clinical-outcome evidence is meaningful but still developing - primary trials cited above demonstrate NAD+ elevation and signal-level physiological effects, but large outcome trials in healthy or longevity-focused populations are not yet available. See also Conlon NJ (Plast Reconstr Surg 2022), a narrative review with commercial disclosure that contextualises NAD+ in regenerative medicine. At Vivre, NAD+ is administered under clinical protocol, not marketed as a proven anti-aging therapy.

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Clinical Applications

Indications

Mitochondrial energy support
Component of cognitive optimization protocols
Recovery from neurological insults
Age-related metabolic decline

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Pharmacokinetics

Half-Life & Duration of Action

Half-life is how long a compound stays at active plasma concentration in your body. Most peptides in this catalogue have short plasma half-lives - they clear from your bloodstream within hours, sometimes minutes. The long-half-life compounds in this catalogue are the approved-class incretins (Tirzepatide, Semaglutide, Retatrutide), which are designed for once-weekly dosing - that's the molecular engineering choice that makes weekly dosing work.

Plasma Half-Life

IV infusion: cellular uptake and conversion to NAD+ pools is rapid. The clinical-effect duration depends on cellular NAD+ pool replenishment, not plasma kinetics - typically 24-72 hours of sustained intracellular elevation per infusion.

Why this matters for you

If you don't tolerate a compound or need to discontinue a protocol, short-half-life peptides are out of your bloodstream within hours - not days or weeks. That said, the biological effects they initiate (tissue repair signalling, mitochondrial signalling, gene expression changes) often persist longer than the peptide itself, through downstream cellular cascades. This is normal peptide pharmacology and is important context - the molecule clears fast, but the biology takes longer to wind down.

Evidence Base

Active clinical research area. Strong mechanistic basis. Subjective and biomarker improvements widely reported.

Dosing protocols, administration frequency, and titration schedules are physician-determined at consultation - not published on these public pages. Vivre maintains a separate internal clinical reference for treating physicians.

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Featured In

V-Series Protocols Including NAD+

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Commonly Paired

Compounds Often Prescribed With NAD+

Clinical co-allocation patterns observed in Vivre's allocation history. Pairings are not prescriptions - the physician determines suitability per patient at consultation.

Nootropic Peptide

Semax

ACTH Analog · 10mg

◆ cognitive pair

NAD+ paired with Semax is the core energy-and-plasticity pairing in Vivre's V-02 cognitive protocol - substrate restoration plus neurotrophin amplification.

View Semax detail →

Anxiolytic Peptide

Selank

Tuftsin Analog · 10mg

◆ cognitive trio

Together with Semax and Selank, NAD+ completes V-02's cognitive-architecture protocol - energy substrate plus neuroplasticity plus stress-axis modulation.

View Selank detail →

READY TO PROCEED

Start with the Biological Audit

NAD+ is verified and lot-tested, dispensed following a Biological Audit. The Audit is complimentary for the Batch 001 cohort.

$70 USD/vial

NAD+ · Member rate